Ribozymes correctly cleave a model substrate and endogenous RNA in vivo.
نویسندگان
چکیده
منابع مشابه
Deoxypolypeptides bind and cleave RNA.
We have prepared L- and D-deoxypolypeptides (DOPPs) by selective reduction of appropriately protected polyhistidines with borane, reducing the carbonyl groups to methylenes. The result is a chiral polyamine, not amide, with a mainly protonated backbone and chirally mounted imidazolylmethylene side chains that are mostly unprotonated at neutrality because of the nearby polycationic backbone. We ...
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A NEW FIELD in enzymology has emerged in the past decade with the discovery that RNA can act as an enzyme. First discovered in the cellular RNA-splicing and processing machinery in the form of self-splicing group 1 introns’ and precursor tRNA-processing RNase P (Ref. 2) RNA catalytic activity in a number of smaller RNAs has subsequently been identified3-5. The small, naturally occurring catalyt...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1990
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)44875-7